Axis 5: Biophysics and Systems Biology
Leaders: Pierre-Emmanuel Milhiet and Emmanuel Margeat
Our main objectives are to characterize and better understand the physical mechanisms underlying bio-molecular function using multi-scale approaches, from individual molecules to the cell. We are using and developing ensemble and single molecule biophysics techniques as well as multi-scale modelling of the biological processes (systems biology) to take into account the stochasticity and complexity of biological functions. We are also developing multifunctional peptide-based systems for in vivo targeted-delivery of therapeutic molecules.