Axis 1: Genome and Epigenome
Leaders: Robert Feil and Bernard De Massy
Covalent modifications on the DNA and the proteins that organise the chromatin are stably maintained in specific cell lineages and tissues. These modifications together constitute the epigenome and modulate nuclear functions. This Axis explores genomic and epigenomic regulation and unravels their importance in cellular identity, development and human disease. It brings together twelve teams who investigate diverse biological functions, including chromosome compaction, DNA replication, meiotic recombination, DNA damage repair, gene expression and RNA processing.